Clinical Pathophysiology


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The Clinical Patho-Physiology Course (CPP) serves as a transition from the basic medical sciences to clinical medicine.   The goal of this course is to establish a knowledge base for various clinical problems encountered in Internal Medicine, and will introduce the fundamental concepts of pathophysiology in the clinical setting.  The most important information will be the processes of disease and how they present themselves clinically.  The faculty will introduce students to the basic principles through a series of diverse seminar lectures and other various methods.   Topics presented in this seminar series will include cardiology, pulmonology, infectious disease, hematology, nephrology, gastroenterology, rheumatology, neurology, oncology and endocrinology.

The structure of this course is made up of various methods.  In addition to lectures, where the presentation style will differ according to particular clinical faculty preferences and lecture goals, there are Integrated Pathology-CPP Sessions (IPCS), Team-Based Learning (TBL) exercises and Directed Learning/Interactive Case Discussions. 

Integrated Pathology-CPP sessions (IPCS):

In conjunction with Pathology faculty, CPP faculty will deliver a Clinical Pathological Correlation-styled interactive learning session.

Attendance: Mandatory

Frequency: Irregular


Coronary Artery Disease


Lower Respiratory Tract Infection

Hematuria/ GN

Lung tumors


Joint disease

Directed Learning/ Interactive Case Discussion:

A set of required podcasts/ audio-video modules/ You-tube videos/ Journal articles will be posted on the course calendar for students to review during each organ system block (Directed Learning). Subsequently, faculty (Topic Coordinator or assignee) will lead the students in an hour long interactive case discussion relevant to directed material (Interactive Case Discussion).

Directed Learning:

Podcast Review (PR)

Review of Article (RA)

AV module (IAVM)

Attendance: Not applicable

Frequency: Variable




Pleural Effusions/Pulmonary Emboli

Students are responsible for all material.

While we encourage the faculty to present at an M2 level, unfamiliar concepts and terms are common.  Please feel free to ask questions.   If you have questions about material covered in class, it is always best to consult with the individual instructor first. If you still have questions, please do not hesitate to contact the course TA listed below.

Wael Youssef Course Director
Wael Youssef
(217) 383-4612
Carle Forum
611 W. Park
Urbana, IL 61801
Richard Travers Teaching Assistant
Richard Travers
(217) 383-4612
Carle Forum
611 W. Park
Urbana, IL 61801
Tracey Johnson Coordinator
Tracey Johnson
(217) 383-4612
Carle Forum
611 W. Park
Urbana, IL 61801
Textbooks and Materials

Required Textbooks

Pathophysiology of Disease: An Introduction to Clinical Medicine, 7th Edition by McPhee, SJ., et al. (eds.), Lippincott, Williams and Wilkins

Recommended Textbooks

Cecil Essentials of Medicine, 8th Edition by Andreoli T, et al. (eds.), Philadelphia : Saunders, W. B.
Harrison’s Principal of Internal Medicine, 8th Edition by Braunwald, E, et al. (eds.), New York : McGraw-Hill
Marriot’s Practical Electrocardiography, 12th Edition by Wagner, GS, Philadelphia : Lippincott, Williams and Wilkins
Step up to Medicine, 3rd Edition by Agabegi, SS, et al. (eds.), Philadelphia : Lippincott, Williams and Wilkins
Symptom to Diagnosis An Evidence Based Guide, 3rd Edition by Stern, S, et al. (eds.), McGraw-Hil

Assessment Description Percent
Exam 2 Cardiology 22%
Exam 3 Pulmonology/Renal 24%
Exam 4 Hematology/Oncology 9%
Exam 5 Musculoskeletal 6%
Exam 6 Oncology/Women's Health 7%
Exam 7 Gastroenterology/Endocrinology 24%
Exam 8 Neurology/Addiction Medicine 8%

The grade for this course will be based on seven multiple choice exams given throughout the year. The pathophysiology exam questions are typically "board style" questions with a clinical stem followed by 5 possible multiple choice answers. There will be a minimum passing level for each exam. The course will be graded as a year-long course (for a total of 14 semester hours) with the final course grade determined on the basis of the scores for the year (the total of the 7 exams).

NOTE: UI COM HAS IMPLEMENTED A "FLOATING MPL" SYSTEM DETAILS OF WHICH MAY BE OBTAINED FROM THE OFFICE OF ACADEMIC AFFAIRS. SUFFICE TO SAY THAT THE MPL FOR THE COURSE WILL BE BETWEEN 60 - 65%.  If students fail the course (achieve<60-65% total on the 7 exams), a comprehensive make-up exam will be given. The make-up exam usually consists of multiple choice questions from the year-long course but the Course Director reserves the right to determine the type of make-up examination.

Should a student fail to achieve a minimum passing level (MPL) for the examination series, the M-2 guidelines as described in the College of Medicine's Student Promotion Policy (including remedial work and a make-up examination) will be followed.

The course TA will conduct a review session prior to each exam; dates and times will be announced later in the semester. Semester and final grades (O: Outstanding, ADV: Advanced, PR: Proficient, and NR: Needs Remediation) will be assigned according to a curve distribution scale consistent with UICOM policies for the M2 year.


Topic Coordinators

Most organ system topics will have a topic coordinator who is a faculty member in charge of that topic. This person will coordinate lectures, submit exam questions, and oversee independent study topics for his or her particular topic. The topic coordinators will work closely with the course director on each of these issues. Please contact the topic coordinators directly to obtain office hours. The various topic coordinators are listed below.

Cardiovascular Naveed Adoni, MD
Pulmonary Danish Thammem, MD
Nephrology Jean Holley, MD
Infectious Disease Janet Jokela, MD
Hematology Vamsi Vasireddy, MD
Rheumatology Mehmoodur Rasheed, MD, FACR
Endocrine Kingsley Onyemere, MD
Gastroenterology Wael Youssef, MD
Neurology Graham Huesmann, MD, PhD
Emergency/Extreme Weather
If conditions require the cancelling of classes or closure, the college will broadcast an announcement on this website, Facebook, Twitter, and Google+.

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