Hydropic change is one of the early signs of cellular degeneration in response to injury. Hydropic change refers to the accumulation of water in the cell. This is clearly seen in this slide. Note the large clear cells occupying 95% of the field. Note that the lumina of the tubules are closed by swollen epithelial cells. Compare with normal kidney tubules. The accumulation of water in the tubular cells is usually due to hypoxia of the tissue with a resultant decrease in aerobic respiration in the mitochondria and a decreased production ATP. Also note the central hypercellular glomerulus.
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