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Image Number 107 - Heart, rheumatic myocarditis, mature Aschoff nodule

This aggregate is an Aschoff body (synonymous with the Aschoff nodule which is also synonymous with the rheumatic fever nodule). These pea sized, painless nodules are found through&127;out the body, most typically in the heart. The fully mature nodule is composed of a central focus of fibrinoid necrosis surrounded by Aschoff/Anitschkow cells or myocytes (the major cell type seen here), which sometimes form giant cells of Aschoff (not seen here) along with an extensive collagen matrix, and some leukocytes.

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