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Image Number 116 - Spleen, typhoid fever, reactive splenic vasculitis

Typhoid fever is caused by Salmonella typhi, which gives rise to an inflammatory destruction of the mucosa of the G.I. tract. Typhoid fever also has a bacteremic phase which can cause splenomegaly due to involvement of the spleen. In this slide, is seen one of the complications of S. typhi, namely destruction of the blood vessels of the affected organ. Note the large leukocytic infiltrate in the vessel wall. Typhoid fever should not be confused with typhus which is caused by rickettsiae.

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