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Image Number 121 - Lymph node, medistinal, histoplasmosis

Histoplasmosis is a fungal infection prevalent throughout the Mississippi River Valley. The characteristic lesion is the granuloma seen here in the hilar lymph nodes. It most commonly infects the lung and does not spread. However, in the immunosuppressed patient, it can disseminate. At a higher power, it would be possible to see the yeast forms of H. capsulatum within the macrophages found throughout the granuloma. Note the ring of lymphocytes around the granuloma.

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