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Image Number 34 - Heart, metastatic melanoma, gross

Melanin is a brown-black pigment produced by the melanocytes of the skin, the choroid of the eye and the substantia Nigra of the brain. In the skin, normal melanocytes do not retain the pigment they produce, but transfer it to the surrounding keratinocytes. In malignant melanoma, the cells retain their pigment as they proliferate and metastasize throughout the body. This is seen in this slide as the black pigmentation in the heart.

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