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Image Number 37 - Kidney, lupus nephritis

In lupus nephritis, immune complexes are deposited in the basement mebranes of the glomeruli of the kidney. This gives a characteristic immunofluorescent pattern, as seen in this slide and often referred to as a lumpy-bumpy pattern. 90% of the slide is occupied by 1 glomerulus which has been visualized by fluorescein isothiocyanate (a chromophore that fluoresces green under UV light) conjugated to anti-IgG antibody. Because immune complexes are being deposited as opposed to antibodies directed against the basement membrane itself, a "lumpy-bumpy" appearance is seen. A smooth immunofluorescence pattern is typical of Goodpasture's disease.

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