Rheumatic fever (R.F.) is diagnosed on the basis of criteria established by Dr. T. Duckett Jones (commonly known as the Jones criteria). Subcutaneous nodules (rheumatic fever nodules/Aschoff nodules) or bodies are one of those criteria. Such a nodule is seen here. These nodules are characterized by two principal histologic features: a central focus of fibrinoid necrosis, with a leukocytic infiltrate, and Aschoff/ Anitschkow cells or myocytes which are "plump" macrophages. (Perhaps some of the large open cells seen in the mass of collagen in the center of the screen are Aschoff cells).
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