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Cardiovascular Volume

Image Number 013

Rheumatic fever (R.F.) is diagnosed on the basis of criteria established by Dr. T. Duckett Jones (commonly known as the Jones criteria). Subcutaneous nodules (rheumatic fever nodules/Aschoff nodules) or bodies are one of those criteria. Such a nodule is seen here. These nodules are characterized by two principal histologic features: a central focus of fibrinoid necrosis, with a leukocytic infiltrate, and Aschoff/ Anitschkow cells or myocytes which are "plump" macrophages. (Perhaps some of the large open cells seen in the mass of collagen in the center of the screen are Aschoff cells).

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