Adenoma, adrenal cortex

The entire nodule is surrounded by an extensively vascularized capsule. This rather non-descript appearance is typical of the adenoma. The resulting pathophysiology from an adrenocortical adenoma is a result of the hormone that is produced in excess. If the tumor arises from the zona glomerulosa then excess mineralocorticoids are produced - e.g. Conn's syndrome. If the tumor arises from the zona fasciculata there will be excess glucocorticoids - e.g. Cushing's syndrome. If the tumor arises from the zona reticularis then there will be excessive androgens in the system resulting in virilization.