Pituitary, steroid-induced basophil suppression, high power

Notice that in this specimen that the majority of the cells are eosinophilic cells = the large cells with the pink staining cytoplasm found throughout the field. There is a cluster of chromophobes in the top central portion of the screen, recognizable as those cells whose nuclei have a large clear space around them. No basophils are clearly seen in this field.

Basophils produce ACTH. Exogenous administration of corticosteroids will predictably inhibit the production of ACTH in the pituitary as seen in this specimen.