Malignant nephrosclerosis

Malignant nephrosclerosis is the renal manifestation of malignant hypertension. There are three histological changes seen in the kidney in this condition: 1) fibrinoid necrosis of the arterioles,2) hyperplastic arteriolosclerosis also called "onion-skinning" of the arterioles seen here in the vessel in the center of the screen, 3) glomerulitis as seen in the hypercellular glomerulus at 7 o'clock on the screen. Note that this is not a true "itis" or inflammation in that the hypercellularity is due to the proliferation of the juxta-glomerular cells and is not due to a leukocytic infiltrate.