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URBANA ATLAS OF PATHOLOGY

Image Number 31 - Cytomegalovirus Infection

This is a classic example of the nuclear inclusion body seen with CMV infection and it is this histological presentation that is the basis for the naming of this virus. Note, close to the center of the field, the large dark pink nuclear inclusion body surrounded by a clear halo. CMV also causes the development of cytoplasmic inclusions, seen as granules throughout the cytoplasm of the infected cells. Other viruses also cause the formation of inclusions, e.g. herpes, variola, rabies, hepatitis B, etc. It is important to be able to recognize these inclusions in histology specimens

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